2018

In recent years, while many issues have been raised related to food safety and the environment, the safety of textiles, which are indispensable for everyday life, has become a particular concern.

EDX-FTIR Contaminant Finder/Material Inspector

LC/MS/MS Screening Software

In the revised RoHS Directive (RoHS 2.0), four types of phthalic esters were added to the list of regulated substances in July 2019. Although GC-MS is generally used, soft PVCs and certain other products include materials with high concentrations of phthalic esters, and if these are analyzed by GC-MS, they may place an excessive load on the column used. Because FTIR enables quick spectrum measurement without pretreatment, it is suitable for determining whether samples contain high or low concentrations of phthalic esters.

This pretreatment kit for human biological samples is intended for the field of forensic medicine.

Designed and intended specifically for use under low pH condition, Shim-pack Velox SP (Sterically Protected)-C18 offers a well balanced retention profile with a long life time even under harsh, acidic condition needed for LC/MS(/MS) analysis.

The triple quadrupole mass spectrometer is widely used in various application fields to quantify the trace amount of compounds in real world samples because of its excellent sensitivity and selectivity. In order to achieve lower limit of quantitation, many researchers have been developing new desolvation technologies at either ESI sprayer or MS inlet.
Here, we report the higher sensitive triple quadrupole mass spectrometer equipped with novel desolvation devices such as addition of the heated gas blowing along with electrospray and the heated multi-orthogonal ion path mounted at the inlet of mass spectrometer. The combination of the heated gas at ESI and heated multi-orthogonal ion path enhanced desolvation efficiency which resulted in low femto-gram limit of quantitation.
Several commercially available drug samples (Reserpine, Verapamil, Alprazolam, Carbamazepine, Cilostazol, Lidocaine, Fluticasone and Testosterone) were prepared for the sensitivity evaluation of higher sensitive triple quadrupole mass spectrometer equipped with the modified ESI source and the heated multi orthogonal ion path. All the samples were analysed by the Multiple Reaction Monitoring (MRM). MRM parameters including MRM transitions and collision energy as well as compound dependent ion transfer voltages were optimised through automatic MRM optimization functionality incorporated in LabSolution software (Shimadzu Corporation, Kyoto, Japan).The temperatures of heated gas and heated multi-orthogonal ion path were optimised for each sample.
Using modified ESI source and the heated multi orthogonal ion path helped to deliver a limit of quantitation for all eight drugs below 5 fg/uL. The temperature of heated gas and heated multi-orthogonal ion path were independently optimised for each sample with the range of 200 to 500 degree C and 150 to 300 degree C respectively. The ion intensity of reserpine was increased 8 times with the heated gas and 4 times with heated multi-orthogonal ion path operated at 300 degree C. Besides larger volume of Ion was introduced into the mass spectrometer by the effective desolvation, the base line noise was maintained at reasonably low level as the noise derived from neutral droplet or unwanted ions were strongly reduced in the multi orthogonal region heated at high temperature, and resulted in excellent signal to noise ratio which achieved low femto-gram sensitivity.

Amino acid composition analysis has traditionally been conducted for protein quantitation and peptide structure prediction. Its use has also extended in recent years to the quantitation of such functional components as branched chain amino acids (BCAA). Previously, in Application News No. L432 and L437, we introduced examples of analysis of amino acids subjected to fluorescence derivatization using o-phthalaldehyde (OPA) using the SIL-30AC. Here, we introduce an example of fast analysis of amino acids in proteins.

When analyzing biological samples featuring a large number of matrix components, however, separation from the matrix can be difficult using GC-MS.An alternative is GC-MS/MS, which provides excellent separation performance via MS.In this Application Datasheet, an analysis of metabolites in rat urine is performed using GC-MS/MS.Results comparing this data with GC-MS data are also introduced.

The Shimadzu GCMS-TQ8040 NX is the first triple quadrupole with Smart Productivity for high efficiency sample throughput, Smart Operation for quick and easy method development, and Smart Performance for low detection limits and Scan/MRM.

Designed and intended specifically for use under low pH condition, Shim-pack Velox SP (Sterically Protected)-C18 offers a well balanced retention profile with a long life time even under harsh, acidic condition needed for LC/MS(/MS) analysis.

IRSpirit, Ready to Run, Compact FTIR that travels where it's needed.

eMSTAT(easy mass spectrometric statistical) Solution enables easy statistical analysis of MALDI-TOF MS/DPiMS measurement data by anyone.

IMAGEREVEAL MS is comprehensive image analysis software that can “reveal” the images hidden in a large amount of data. Different software licenses are available tailored towards different analysis goals.

Faster Response and Higher Stability

The analysis of dioxins in foods was mainly performed using magnetic sector (double-focusing) GC-MS instruments.

IRSpirit, Ready to Run, Compact FTIR that travels where it's needed.

Greater Simplicity and Reliability in the Determination of Amino Acid Sequences Software Compliant w...

The LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer integrates the world's fastest and most sensitive quadrupole technology with TOF architecture.

The LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer integrates the world's fastest and most sensitive quadrupole technology with TOF architecture.

Analyses of biosimilar were performed by LCMS-9030 quadrupole-mass spectrometer with the Nexera Bio LC system. This application provides the peptide mapping of Monoclonal antibody for full peptide sequence. The tryptic peptides are identified on the mass chromatogram and each mass spectra are detected with a mass error within +/- 5 ppm. 100% of all peptide sequence from the digested bevacizumab biosimilar sample was achieved.

Complete method for fast quantitative screening of 13 aminoglycosides in meat, eggs and milk.

LabSolutions CS features an innovative operating environment and provides complete data management to ensure secure information in networked laboratories.

Fully Automated Sample Preparation Module for LCMS

Of the short-chain fatty acids produced by intestinal bacteria, acetic acid, propionic acid, and butyric acid are well known, and it has been reported that there are some connections between them and lifestyle-related diseases such as obesity and diabetes.

Greater Simplicity and Reliability in the Determination of Amino Acid Sequences Software Compliant w...

Palm oil is an edible oil extracted from the fruit of oil palm (Elaeis guineensis). Due to the abundance of oil palm in Southeast Asia and Africa, as well as its relatively lower cost, palm oil has become one of the largest contributors to the global oil market. Crude palm oil (CPO) is usually refined, deodorized and bleached for wider usages such as domestic cooking and food processing. The quality of processed palm oil is governed by several factors such as the oxidative status, stability, bleachability and purity of CPO. Therefore, the quality of CPO is essential for the production of high-quality refined palm oils. Ultraviolet-visible (UV-VIS) spectrophotometers are widely used for qualitative and quantitative analysis due to its ease-to-use operation and short sample analysis time. In this application news, Shimadzu UV-1280 UV-VIS spectrophotometer, a combined monitor double beam spectrophotometer was used for the analysis of CPO and refined palm oil products.

Smart Forensic Database Ver. 2 supports the creation of MRM methods for forensic toxicological substances.

The Nexera Mikros can be used to detect target components with higher sensitivity than with semi-micro flowrate compatible LCMS systems, which perform measurements within a flowrate range of 100 μL/min to 500 μL/min.

Mycotoxins are highly toxic chemical byproducts from fungi commonly found in crops, and residual content in foods are regulated the world over.