The Nexera Mikros system delivers the improvements you expect from a low-flow system with the ruggedness of HPLC. A plasma blank was protein precipitated, diluted (3x), and...
Nexera Mikros
Supporting Micro Flowrate Range Liquid Chromatography Mass Spectrometry System
Microflow Liquid Chromatography Mass Spectrometry System
Micro: Above and Beyond Nano
The High Sensitivity You Expect from a Low Flow System with the Ruggedness of HPLC Covering the Complete Range from Micro to Semi-Micro
LC/MS/MS methods are now widely recognized as gold standard for the accurate quantitation of small molecules in biological fluids and results more suitable and reliable compared to immunoassay based approaches. For metabolites in biological fuids, the concentration level of the target component is often low, therefore more sensitive analysis is required than semimicro-flow LC/MS analysis, which is superior in analytical throughput, stability and robustness. Generally, in LC/MS analysis, improvement of sensitivity can be expected by reducing the analytical scale which is defined by the total flow rate and column size. On the other hand, by reducing the analytical scale to nano-flow, a well skilled analysts who have special technics in nano-flow analysis is required, and throughput, stability and robustness are reduced by trade-offs. LC/MS analysis on a micro-flow scale using 0.1 to 1 mm I.D. column with 1 to several μL/min has the excellent balance of sensitivity, throughput, and robustness. Nexera Mikros, a Shimadzu microflow LC/MS system provide the stable and sensitive quantitative analysis by not only improved sensitivity through stable performance of micro-flow solvent delivery and optimized ion source design, but also utilization of the unique UF-Link column connection and system variety that support a wide range of applications.
Features
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Realize the Benefits of Microflow While Enjoying the Ruggedness and Reliability of HPLC
The Nexera Mikros system delivers the improvements you expect from a low-flow system with the ruggedness of HPLC. A plasma blank was protein precipitated, diluted (3x), and...
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Applications
Applications | Creation Date |
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2020-10-21 |
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2019-05-30 |
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2019-05-29 |
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2018-10-01 |
News / Events
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User interviews December 2020
Our field of activity is contract research and testing for life sciences industries including pharma, biotech, nutraceuticals, environmental sciences, food&agri testing, and diagnostics.
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LCMS Food Safety Application is now available.
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Application Note: "Analysis of Pharmaceuticals' Impurity - Regulations and Analysis for Carcinogenic Substances -"
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Application Note: "Various Analysis Techniques for Organic Acids and Examples of Their Application"
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Shimadzu has released the Metabolites Method Package Suite.
Provides ready-to-use methods for over 1900 metabolites
This suite allows comprehensive analysis of over 1900 metabolites without the need for investigation of separation conditions, MRM optimization or parameter settings. -
Direct Probe Ionization Mass Spectrometer - APPLICATION NOTEBOOK -