Comprehensive 2D-LC is a analytical methodology combining two independent separation modes orthogonally, greatly increasing separation efficiency.
Nexera-e
Comprehensive Two-Dimensional Liquid Chromatograph
Comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation. By combining two independent separation modes orthogonally in combination with a dual-loop/dual-valve alternate switching design, the highest possible peak capacity is achieved.
The new Nexera-e is the ideal solution for the separation and characterization of most challenging and complex samples. It is particularly useful for the analysis of pharmaceutical impurities, proteolytic digests, food extracts, natural products and synthetic polymers.
Separation far exceeding conventional 1D-LC
How many peaks are co-eluted under one peak? The more complex the sample, along with a high percentage of similar compounds, there exists a high probability of co-eluting compounds found under single peaks.
Even though the co-eluting compounds may not be separated by mono-dimensional separation, an orthogonal two-dimensional system will provide the best possible result.
Comparison of chromatograms (traditional Chinese medicine)
Features
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Shimadzu triple quadrupole mass spectrometers (TQMS) have the world-class polarity reversal speed (5 ms) and data capture speed (1.5 ms). In comprehensive 2D-LC analysis, the analysis time of second dimension is short, therefore the high-speed performance of the LC-MS affects the quality of the data. -
Comprehensive 2D-LC often requires complicated software operation for setting 1D and 2D analytical conditions. LabSolutions provides an easy parameter setting and contributes to the simple operation.
Downloads
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Applications
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2022-12-02 |
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2016-05-31 |
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2016-05-31 |
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2016-02-05 |
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2015-06-23 |
Movies
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Nexera-e (Comprehensive Two-Dimensional Liquid Chromatograph)
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Comprehensive 2DLC: Concepts, Potential, Applications
News / Events
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Shimadzu has released the Nexera MX.
Nexera MX processes twice the number of samples as conventional LCMS systems in the same amount of time.
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“Advanced i-Series” High Performance Liquid Chromatograph
Retaining the excellent basic functions of the flagship “i-Series”, the Advanced i-Series boasts increased pressure resistance and additional functions to support remote work including working from home.
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Shimadzu has released the ELSD-LT III Evaporative Light Scattering Detector for HPLC.
The evaporative light scattering detector (ELSD) is a general-purpose universal detector that can even detect components with no UV absorption, such as carbohydrates, lipids, surfactants, and synthetic polymers.
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Shimadzu has released the Microsampling Device, MSW2™ Type Udck™
For Research Use Only. Not for use in diagnostic procedures.
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Shimadzu has released Shim-pack MC PLONAS Series.
Shim-pack MC PLONAS 2.7 μm columns reduce the back pressure yet maintain the performance of a sub 2 μm fully porous particle column. The pressure limit is 40 MPa.
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Application Note: "Analysis of Pharmaceuticals' Impurity - Regulations and Analysis for Carcinogenic Substances -"